If you’re living with dry AMD, you may be at risk for developing geographic atrophy, or GA.

GA can be unpredictable—and progress rapidly—leading to irreversible vision loss.

Now there's something you can do to...

Slow. It. Down.

Get it goin’ slower.

Ask your doctor about IZERVAY.

I. ZER. VAY.

Gets GA goin’ slower.

IZERVAY is an eye injection.

Don’t take it if you have an infection or active swelling in or around your eye.

IZERVAY can cause eye infection, retinal detachment, or increased risk of wet AMD.

IZERVAY may temporarily increase eye pressure.

Do not drive or use machinery until vision has recovered after an eye injection or exam.

IZERVAY is proven to slow GA progression which may help preserve vision longer.

I. ZER. VAY.

Gets GA goin’ slower.

So shift gears and get going.

Don’t delay. Ask your doctor about IZERVAY.

Our vision. It’s how we connect with our world...

our loved ones...

and it’s how we navigate our daily lives.

But what happens when our vision is compromised?

Geographic Atrophy, or GA, is an advanced form of dry age-related macular degeneration, or AMD, that leads to irreversible vision loss.

If you have GA, you are not alone. 1.5 million people in the US have GA.

In fact, 67% of people with GA in both eyes can lose their ability to drive in 1.6 years.

And within two years, 50% lose 2 lines of vision on an eye chart.

Given how quickly it can progress, every month matters when it comes to slowing the progression of GA.

But just what is GA?

GA is a disease that affects the retina, which is the part of your eye that converts light into signals that your brain turns into images.

At the center of the retina, the macula helps you see detail.

At the center of the macula, the fovea is responsible for your sharpest and clearest vision.

When dry AMD progresses to GA, cells in your retina die.

This leaves behind patches of dead cells called “lesions” that can spread and cause vision loss.

GA’s progression can be fast. In as few as 2.5 years, lesions can spread and reach the fovea, leading to irreversible vision loss.

There’s something you can do to slow down GA.

Ask your doctor today—about IZERVAY.

IZERVAY is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

IZERVAY is proven to slow GA progression, which may help to preserve vision for longer.

IZERVAY was evaluated in 2 clinical trials. In both trials, GA progression was slower for people receiving IZERVAY compared to those that were not treated.

In Trial 1, IZERVAY slowed progression by 35%. In Trial 2, IZERVAY slowed progression by 18%.

The most common side effects include: blood in the white of the eye, increased eye pressure, blurred vision and wet AMD.

IZERVAY works by targeting a key source of retinal cell death and loss of photoreceptors.

Here’s how. With GA, part of the immune system becomes overactive.

As a result, a protein called C5 signals other proteins to start attacking retinal cells. IZERVAY blocks the C5 protein to help protect healthy retinal cells and photoreceptors.

IZERVAY is an eye injection given in the office by your doctor.

To receive the full benefit of IZERVAY, you should follow your doctor’s recommendation for continuous treatment.

If you need help with the cost of IZERVAY, the IZERVAY My Way^SM financial assistance program may be able to help.

Our vision is how we navigate our lives—if you have GA, it’s time to act.

To slow progression of GA, start today—with IZERVAY.

The earlier you act, the more you may protect for longer.

To learn more, ask your doctor about IZERVAY.

Do NOT receive IZERVAY if you have an infection in or around your eye

Have active swelling in or around your eye that may include pain and redness

Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).

Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.

There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.

IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine
• Are taking any medications, including prescription and over-the- counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

The most common side effects of IZERVAY are:

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at
1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full prescribing information for more information.

Hello, my name is Doctor John Kitchens.

I’m a vitreoretinal surgeon and partner at Retina Associates of Kentucky in Lexington, Kentucky. Today, I’d like to talk to you about dry age-related macular degeneration. It can progress to an advanced form called geographic atrophy, or GA. And GA can lead to irreversible vision loss.

It’s so important to diagnose GA early, so you have the opportunity to start treatment to slow its progression. This is extremely important because many of my patients don’t realize that the clock is ticking. They think they have time, but GA is definitely not a wait-and-see situation.

Geographic atrophy, or GA, is a type of dry macular degeneration. It results when you lose a tissue layer in the back of the eye called the retinal pigment epithelium.

The retinal pigment epithelium supports the retina. It helps the retina function. And when you lose that tissue, unfortunately, over time, the overlying photoreceptors in the retina, they’re lost as well. The result is permanent vision loss.

To diagnose and monitor progression of GA, we use imaging techniques such as optical coherence tomography, fundus autofluorescence, and color fundus photography. All of these tests help us visualize the layers of the retina and the layers under the retina, and identify any lesions or other atrophic changes before GA significantly impacts vision.

Now imagine how this could look if diagnosis and treatment occurred earlier in the disease.

You know, most patients understand immediately what’s happening with their eyes when they see scans like this. It’s almost like a time machine. We can go back in time and say, this is what your retinas looked like two years ago. This is how much atrophy you had two years ago, and here’s where it’s progressed to.

The progression rate for GA can really vary. Some patients may experience rapid changes while others have a slower progression.

I tell my patients it’s impossible to know the speed of progression, so it’s important to treat early. Regular monitoring is crucial to track changes and adjust the treatment plan as needed.

While treatment will not reverse damage, early intervention can slow the progression of GA. So there’s an urgency for slowing progression, which can help preserve remaining vision for longer. This can help the patient continue their routine and independence for longer, potentially to delay their need for adaptive aids such as magnifiers and large-print materials.

IZERVAY works to slow GA progression by directly targeting C5, a key source of retinal cell death and loss of photoreceptors.

The earlier you act to receive treatment with IZERVAY, the longer we may be able to preserve your vision.

I think IZERVAY gives patients the belief that this is a good first step, that it really helps to give them some degree of hope that they’ll have more time with their vision.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

Chapter 1: What to know about geographic atrophy, or GA.

The easiest way to explain the importance...

...of keeping your eye...

...on GA, or geographic atrophy,

...is to illustrate the point.

If you’ve been diagnosed with geographic atrophy, or GA, you probably have questions about how and why your vision is at risk, and what comes next.

The first thing to know...

...is that about 1.5 million people in the United States are living with GA,

...so, you’re not alone.

But what exactly is geographic atrophy?

Let’s take a look!

GA is an advanced form of dry age-related macular degeneration, or AMD––a disease that affects the retina.

The retina is the part of your eye that senses light and converts it into signals that your brain turns into images.

The macula is the center of your retina that helps you see details.

And the fovea is responsible for your sharpest and clearest vision.

When dry AMD progresses to GA, an overactive immune response in the eye causes cells in your retina to die, or atrophy, creating patches of dead cells, or lesions, that cause vision loss.

As lesions grow larger, they get closer and closer to the fovea. When they reach the fovea, that’s when severe vision loss occurs.

Unfortunately, vision loss from GA is irreversible, and GA progression can’t be stopped. But there are ways to slow it down.

That’s an important thing to ask your doctor about.

So what does GA mean for you?

How will GA affect my vision?

You may not have symptoms today, or they may seem manageable, but it’s important to think about how GA progression...

...may affect your vision in the future.

The symptoms of GA can include blurry vision,

...seeing dull or washed-out colors,

...or having difficulty seeing in low light or at night.

As GA progresses, and lesions grow closer to the fovea, more severe vision loss can occur,

...like blank spots in your field of vision obscuring friendly faces,

...or straight lines looking wavy or crooked.

GA is unpredictable, but it will certainly progress over time. How quickly and how much is different for everyone.

In as few as two and a half years, GA can spread to the fovea, causing irreversible vision loss.

Hmm. Hmm?

Remember, even if you don’t have symptoms yet, GA can still be progressing.

The future of your vision is why slowing GA is so important, and now is the time to talk to your doctor about slowing GA progression early with treatment.

Chapter 2: Benefits of treating geographic atrophy —or GA—early.

Why start GA treatment early?

Because GA can progress faster than you think. Vision loss from GA can interfere with your routine and independence.

In 1.6 years,

...67% of people with GA in both eyes lost the ability to drive.

And in 2 years, half of the people with GA...

...lost 2 lines of vision on an eye chart.

GA is like a runaway train. So, the goal of early GA treatment is to slow progression of GA,

...which may preserve vision for longer...

...because GA progression can’t be stopped.

The vision loss it causes is irreversible...

...and it’s hard to know when GA progression will accelerate.

So the earlier you start a treatment plan together with your doctor...

...the sooner we can start to slow down GA progression!

Being proactive with early treatment, and staying on treatment as recommended by your doctor, may slow down GA’s impact to your vision.

So don’t miss your opportunity to preserve your vision for longer.

Let’s start treatment today.

Chapter 3: Slow geographic atrophy—or GA—with IZERVAY (avacincaptad pegol).

Let’s talk about IZERVAY.

IZERVAY is a prescription eye injection that is an FDA-approved treatment proven to slow GA progression.

It’s important to know some safety information about IZERVAY. Do not take IZERVAY if you have an infection or active swelling in or around your eye. Watch this entire video for more Important Safety Information.

So, how does IZERVAY work?

In people with GA, a part of the immune system becomes overactive.

A protein...

...called C5...

...signals other proteins to start attacking retinal cells.

Only IZERVAY...

...blocks the C5 protein to help protect healthy retinal cells and photoreceptors.

IZERVAY is proven to slow GA progression...

...which may help preserve vision longer. IZERVAY is an eye injection...

...given in the office by your doctor.

The idea of an eye injection may sound scary, but it is a common medical procedure.

To prepare, your doctor will clean and numb your eye to help reduce discomfort.

The injection typically takes a few seconds. You may feel pressure in the eye but, usually, little to no pain. Afterwards, you may experience eye redness, blurry vision, or an increase in eye pressure.

It’s important to follow your doctor’s post-treatment care instructions...

...and call them right away if you think you might be experiencing side effects.

Staying on treatment as recommended by your doctor is important to receive the full benefits of IZERVAY.

The earlier you slow GA progression, the longer you may preserve your vision.

Hmm...

So, what’s important to you as you think about your vision?

Hmm...

Don’t delay. Talk to your doctor about...

...slowing GA—with IZERVAY!

Stay tuned for Important Safety Information, and then the main feature—you, teaming up with your doctor.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

Mom and I, we’ve always had a very close relationship, and we love to travel together.

Jan and I click, and we have so much fun together. I—I can’t imagine travelling with anyone else.

I mean she’s my mom, but she’s also my best friend.

And we laugh. Every day she makes me laugh, so… I love her. What can I say?

In my thirties, I had an eye procedure, and they noticed there was something was wrong with my retina. I was referred to my current eye doctor, Dr. Yackey. She performed a series of tests, and when the results came back, she told me that I have macular degeneration.

Later, my eye doctor told me that my macular degeneration had progressed into geographic atrophy, or GA. Why is this happening? Why am I losing my eyesight? It was just really hard.

I was scared to death that I was going to go blind. I was scared that I was going to have to give up work and go on disability.

Macular degeneration is a condition that leads to significant vision loss in the advanced stages. Once atrophy starts to form, we cannot bring back vision. That means that there’s geographic atrophy. When Jan was first diagnosed with geographic atrophy, I explained to her that she would slowly lose her vision.

When Dr. Yackey told us that Jan was losing her eyesight, I asked Dr. Yackey, “Please, could I give her one of my eyes?” My heart breaks for her that she’s going through this when it should be me at my age, not her at her age.

I love to cook, and now, Mom has to help me measure things out so I’m not as independent as I once was. In my forties, my eyesight started to get worse, and it was harder to drive at night. Later, I even noticed my eyesight getting worse in the daylight. That terrified me.

It was scary when she pulled over and said, “Mom, I can’t drive anymore.” She gave up her driver’s license, which I was very proud of her for that.

My eye doctor referred me to a retina specialist, who told me about a treatment for GA called IZERVAY.

Once I referred Jan to the retina specialist for treatment, they talked about her treatment options, and one of the potential options that we have today is to introduce her to IZERVAY.

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection used to treat geographic atrophy, the advanced form of dry age-related macular degeneration.

The goal of the medication is to slow the progression of geographic atrophy. Slowing geographic atrophy progression may help preserve vision longer.

I decided to give IZERVAY a chance because it was hope.

When I went to go receive my first IZERVAY injection, I was nervous. I didn't know what to expect. I didn't know if it was gonna be painful, but it was like a big pinch. It wasn't that bad, and it's helping. That's the main thing.

I want to preserve my vision as long as I can, and IZERVAY is helping me do that. This is just my experience, and your experience might be different.

I plan on travelling with my best friend for as long as we both can. Having this time with my mom is a blessing. Being able to do things together, have fun together…

Laugh together…

Laugh together. It means the world to me.

Yeah, and to me.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.