I’m Babs, social media's favorite grandma…

And proud spokesperson for IZERVAY.

I’m happy to share the importance of good eye health and early disease detection.

My father had vision loss, and for him it turned out to be dry age-related macular degeneration. And now my sister has it, so it obviously runs in my family.

Dry age-related macular degeneration can progress to an advanced form, geographic atrophy or GA.

I’ve learned that GA causes irreversible vision loss.

If you have GA, the sooner you get diagnosed and can discuss options with your retina specialist, the better.

One treatment option to consider is IZERVAY. IZERVAY won't reverse damage from GA, but it can help slow the progression, which may help preserve existing vision for longer.

Talk to your doctor about important safety information such as not taking IZERVAY if you have an active infection in or around the eye or swelling around the eye that includes pain and redness.

So even if you noticed a slight difference in your vision, you need to have that checked immediately.

GA may still be progressing, and it can move faster than you think. That’s why it’s so important to have annual eye exams, so your eye doctor can spot it early.

If you’re diagnosed with GA talk to your doctor about your options, including IZERVAY.

IMPORTANT SAFETY INFORMATION AND USE

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com

What is IZERVAY^TM?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

Hello, my name is Doctor John Kitchens.

I’m a vitreoretinal surgeon and partner at Retina Associates of Kentucky in Lexington, Kentucky. Today, I’d like to talk to you about dry age-related macular degeneration. It can progress to an advanced form called geographic atrophy, or GA. And GA can lead to irreversible vision loss.

It’s so important to diagnose GA early, so you have the opportunity to start treatment to slow its progression. This is extremely important because many of my patients don’t realize that the clock is ticking. They think they have time, but GA is definitely not a wait-and-see situation.

Geographic atrophy, or GA, is a type of dry macular degeneration. It results when you lose a tissue layer in the back of the eye called the retinal pigment epithelium.

The retinal pigment epithelium supports the retina. It helps the retina function. And when you lose that tissue, unfortunately, over time, the overlying photoreceptors in the retina, they’re lost as well. The result is permanent vision loss.

To diagnose and monitor progression of GA, we use imaging techniques such as optical coherence tomography, fundus autofluorescence, and color fundus photography. All of these tests help us visualize the layers of the retina and the layers under the retina, and identify any lesions or other atrophic changes before GA significantly impacts vision.

Now imagine how this could look if diagnosis and treatment occurred earlier in the disease.

You know, most patients understand immediately what’s happening with their eyes when they see scans like this. It’s almost like a time machine. We can go back in time and say, this is what your retinas looked like two years ago. This is how much atrophy you had two years ago, and here’s where it’s progressed to.

The progression rate for GA can really vary. Some patients may experience rapid changes while others have a slower progression.

I tell my patients it’s impossible to know the speed of progression, so it’s important to treat early. Regular monitoring is crucial to track changes and adjust the treatment plan as needed.

While treatment will not reverse damage, early intervention can slow the progression of GA. So there’s an urgency for slowing progression, which can help preserve remaining vision for longer. This can help the patient continue their routine and independence for longer, potentially to delay their need for adaptive aids such as magnifiers and large-print materials.

IZERVAY works to slow GA progression by directly targeting C5, a key source of retinal cell death and loss of photoreceptors.

The earlier you act to receive treatment with IZERVAY, the longer we may be able to preserve your vision.

I think IZERVAY gives patients the belief that this is a good first step, that it really helps to give them some degree of hope that they’ll have more time with their vision.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.